Activation and Oligomerization of Aspartylglucosaminidase
نویسندگان
چکیده
منابع مشابه
Autoproteolytic activation of human aspartylglucosaminidase.
Aspartylglucosaminidase (AGA) belongs to the N-terminal nucleophile (Ntn) hydrolase superfamily characterized by an N-terminal nucleophile as the catalytic residue. Three-dimensional structures of the Ntn hydrolases reveal a common folding pattern and equivalent stereochemistry at the active site. The activation of the precursor polypeptide occurs autocatalytically, and for some amidohydrolases...
متن کاملCharacterization of Aspartylglucosaminidase Activation and Aspartylglucosaminuria Mutations
..........................................................................................................................8 REVIEW OF THE LITERATURE ..........................................................................................9 1. LYSOSOMES ....................................................................................................................9 2. PROTEIN FOLDING, MODIF...
متن کاملPurification and properties of human hepatic aspartylglucosaminidase.
Aspartylglucosaminidase (EC 3.5.1.26), the lysosomal enzyme which hydrolyzes the N-acetylglucosamine-asparagine linkages in glycoproteins, was purified from human liver to homogeneity. The purification procedure included chromatography on DEAE-cellulose and concanavalin A-Sepharose, gel filtration on Sephadex G-200, and high performance liquid chromatography. The purified enzyme had a final spe...
متن کاملConsequent Protein Oligomerization and Primase Activation
243 words 23 Text 5,314 words 24 Copyright © 2010, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved. J. Virol. doi:10.1128/JVI.01690-10 JVI Accepts, published online ahead of print on 10 November 2010 on O cber 0, 2017 by gest http/jvi.asm .rg/ D ow nladed fom Herpes simplex virus type 1 helicase/primase Chen et al.
متن کاملPurification and structure of human liver aspartylglucosaminidase.
We have recently diagnosed aspartylglucosaminuria (AGU) in four members of a Canadian family. AGU is a lysosomal storage disease in which asparagine-linked glycopeptides accumulate to particularly high concentrations in liver, spleen and thyroid of affected individuals. A lesser accumulation of these glycopeptides is seen in the kidney and brain, and they are also excreted in the urine. The alt...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1998
ISSN: 0021-9258
DOI: 10.1074/jbc.273.39.25320